Atrial Natriuretic Peptide (ANP) -Granules of Auricular Cardiocytes in Aging Mongolian Gerbils

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  • MIFUNE Hiroharu
    <I>Institute of Animal Experiment, Kurume University School of Medicine</I>
  • SUZUKI Syusaku
    <I>Institute of Laboratory Animal Science, Kagoshima University, Faculty of Medicine</I>
  • NODA Yasutaka
    <I>Institute of Animal Experiment, Kurume University School of Medicine</I>
  • HAYASHI Yoshihiro
    <I>Laboratory of Veterinary Anatomy Faculty of Agriculture, The University of Tokyo</I>
  • MOCHIZUKI Koshi
    <I>Laboratory of Biomedical Science, College of Agriculture and Veterinary Medicine, Nihon University</I>

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Other Title
  • スナネズミの心耳筋細胞における心房性ナトリウム利尿ペプチド (ANP) 顆粒の加齢に伴う変化
  • スナネズミの心耳筋細胞における心房性ナトリウム利尿ペプチド(ANP)顆粒の加齢に伴う変化〔英文〕
  • スナネズミ ノ シンジ キン サイボウ ニ オケル シンボウセイ ナトリウム

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Abstract

The atrial natriuretic peptide (ANP) -granules of right auricular cardiocytes were studied in aging Mongolian gerbils by immunohistochemistry and transmission electron microscopy, and analyzed by ultrastructural morphometry. Immunohistochemically, the ANP immunoreactions were weaker in 3 and 4-year-old animals than in 90-day-old, 1-and 2-year-old animals. There was no difference in the reaction among 90-day-old, I and 2-year-old animals, or between 3 and 4-year-old animals. Ultrastructurally, the morphological features in 1 and 2-year-old animals were similar to those of 90-day-old animals, but distinct in 3 and 4-year old animals by the presence of a few lysosomal structures in the cell. By ultrastructual morphometry, number and diameter of ANP-granules of 3 and 4-year-old animals were significantly smaller than those in the 90-day-old, 1 and 2-year-old. There was no significant difference in number and diameter among the 90-day-old, 1 and 2-year-old, or between the 3 and 4-year-old.

Journal

  • Experimental Animals

    Experimental Animals 40 (4), 573-577, 1991

    Japanese Association for Laboratory Animal Science

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