Linkage Analysis of Two Murine Polycystic Kidney Disease Genes, <I>pcy</I> and <I>cpk</I>

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  • NAGAO Shizuko
    <I>Laboratory Animal Center, Institute for Comprehensive Medical Science, Fujita Health University</I>
  • TAKAHASHI Hisahide
    <I>Laboratory Animal Center, Institute for Comprehensive Medical Science, Fujita Health University</I>

Bibliographic Information

Other Title
  • 2つのマウス多発性嚢胞腎症遺伝子, <I>pcy</I>と<I>cpk</I>, のリンケージ試験
  • 2つのマウス多発性嚢胞腎症遺伝子,pcyとcpk,のリンケージ試験〔英文〕
  • 2ツ ノ マウス タハツセイ ノウホウ ジンショウ イデンシ pcy ト cp

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Abstract

Two murine models of polycystic kidney disease (PKD) in humans are currently available: the infant-type cpk in mice and the adult-type pcy mutation in mice. Our linkage analysis was to determine whether these genes are allelic forms of the same gene, or infant-type and adult-type PKD resulting from homozygous and heterozy-gous mutation, as in the rat Cy gene. We found that the pcy gene in the mice was linked with the d gene on chromosome 9, but the cpk gene was not. A segregation test indicated that the two genes are inherited independently. This indicates that the cpk and pcy genes are not alleles and that the genetic mechanism of PKD pathogenesis in the mouse is different from that in the Cy rat.

Journal

  • Experimental Animals

    Experimental Animals 40 (4), 557-560, 1991

    Japanese Association for Laboratory Animal Science

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