The Reliable Diagnosis for an Early Stage of Hereditary Muscular Dystrophy of Mice

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  • OZAWA Hikaru
    <I>Department of Pharmacology, Pharmaceutical Institute, Tohoku University</I>
  • AKITA Hirotoshi
    <I>Department of Pharmacology, Pharmaceutical Institute, Tohoku University</I>
  • MIURA Tsutomu
    <I>Department of Pharmacology, Pharmaceutical Institute, Tohoku University</I>

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Other Title
  • 遺伝性筋ジストロフィー症マウスの的確な早期診断法
  • イデンセイ キン ジストロフィーショウ マウス ノ テキカク ナ ソウキ シン

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Abstract

The methods to find hereditary muscular dystrophy mice (dy-mice) were described. One was to observe whether or not mice dragged their hind limbs immediately after they were dropped onto a table following their suspension by their tails. The other was to observe dragging their hind limbs immediately after they were restored to a normal position from a supine one. This limbsdragging induced by these methods were characteristic of dy-mice. Among 437 mice checked by these methods, 76 showed the drag during 14-23 days after birth (18.3 days on the average) and later they were confirmed to be dy-mice without exception. Therefore, it was concluded that these methods were useful for the accurate diagnosis of dy-mice at an early stage.

Journal

  • Experimental Animals

    Experimental Animals 27 (2), 183-185, 1978

    Japanese Association for Laboratory Animal Science

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