Effects of Soft X-Ray Irradiation on Ocular Development in Sprague-Dawley Rats

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  • KUNO Hiroshi
    <I>Banyu Pharmaceutical Co., Ltd., Development Research Laboratories</I>
  • KEMI Masayuki
    <I>Banyu Pharmaceutical Co., Ltd., Development Research Laboratories</I>
  • AKIMOTO Michiyo
    <I>Banyu Pharmaceutical Co., Ltd., Development Research Laboratories</I>
  • FUJII Takaaki
    <I>Banyu Pharmaceutical Co., Ltd., Development Research Laboratories</I>
  • USUI Toshimi
    <I>Banyu Pharmaceutical Co., Ltd., Development Research Laboratories</I>

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Other Title
  • ラットにおける軟X線の眼の発生に及ぼす影響
  • ラット ニ オケル ナンXセン ノ メ ノ ハッセイ ニ オヨボス エイキョウ

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Abstract

Pregnant rats were irradiated with soft x-rays at a dose of 1.6, 3.2, 6.3 or 12.6 Gy on Day 9 of gestation, and the eyes of F1 offspring were examined using indirect ophthalmoscopy and biomicroscopy during Postnatal Week 5. Ophthalmoscopic examination revealed iris and choroidal coloboma, microphthalmia and anophthalmia in the 3.2, 6.3 and 12.6 Gy groups. In addition to those anomalies, lens luxation and associated anterior displacement of the vitreous face, and retinal vascular anomalies were observed in the 12.6 Gy group. Histological examination revealed agenesis of retinal vessels. Ophthalmoscopic examination using biomicroscopy and indirect ophthalmoscopy detected choroidal coloboma, lens and vitreous luxation and defect in retinal vessels which could not be detected by external observation, demonstrating the usefulness of this technique in the postnatal stage of teratology studies.

Journal

  • Experimental Animals

    Experimental Animals 42 (3), 443-449, 1993

    Japanese Association for Laboratory Animal Science

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