Gastric Ulcer in Pigs as an Animal Model of Human Disease

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Other Title
  • ヒト疾患モデルとしてのブタの前胃部潰瘍
  • ヒト シッカン モデル トシテノ ブタ ノ ゼンイブ カイヨウ

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Description

Swine gastric ulcer was investigated from ecological, clinical and pathological view points for its availability as a disease model of human gastric ulcer. Marketed pigs from a piggery showed a high (50%) incidence of gastric erosionulcer of non-glandular region in contrast to pigs from another pig breeder showing no incidence. Responsibilty of fineness of growing and fattening diets for the high incidence in the former group was suggested by an experiment rearing pigs with a ration either fine or coarse particle size. Time-course pursuing of clinical, including gastroscopy, and pathological changes of these pigs revealed an early onset, at an age of 2 months, of the gastric lesion which was led to chronic ulcer at 6 months of age or older. Although the swine gastric ulcer had a common feature to be a peptic ulceration as in human gastric ulcer, being the site was non-gastric juice-producing region having a chance to be immersed with the peptic secretion, the privileged site of ulceration in swine stomach differed from that in human's, and thus, mechanism of generation of ulcer seemed differ between them. Despite, chronicity of the disease course and histological changes characterized by four layers of the ulcerated wall and presence of vascular and nervous lesions indicated a certain similarity to human chronic ulcer suggesting availability of the disease for investigation of some aspects of pathogenesis of chronic, indurated human gastric ulcer. In addition, modifiability of the disease process by means of changing fineness of the deit could have taken advantage than other experimental gastric ulcer produced by various artificial means.

Journal

  • Experimental Animals

    Experimental Animals 28 (2), 287-295, 1979

    Japanese Association for Laboratory Animal Science

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