Electron Microscopy of Cerebellar Neuroblastoma-Medulloblastoma Group

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  • Yagishita Saburo
    Department of Pathology (Neuropathology), Kanagawa Rehabilitation Center

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  • 脳腫瘍の電顕　－小脳芽腫を中心に－
  • ノウシュヨウ ノ デンケン ショウノウ ガ シュ オ チュウシン ニ

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Medulloblastoma is defined as a malignant, invasive embryonal tumor of　the cerebellum in children, predominantly neuronal differentiation and inherent tendency to metastasize via CNS pathways. Cerebellar neuroblastoma, albeit very rare, is subclassifed in medulloblastoma with extensive nodularity and advanced neuronal differentiation. We have encountered these rare cerebellar neuroblastomas, many cases of which have been examined ultrastrlucturally for more than thirty years. Given hallmarks of neuronal differentiation is the presence of developing axons and synapse devices, cerebellar neuroblastoma is very rare, and most cases are equivocal neuroblastoma or medulloblastoma. Glial differentiation is none or minimal. Central neurocytoma is a well defined tumor but it should be born in mind that this tumor contains immature neuronal cells, that is neuroblasts, and “some cases are called neurocytoma-neuroblastoma”, I consider personally.

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