肺結節体積評価のための濃度閾値設定に関する3次元CT画像シミュレーション解析

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タイトル別名
  • 3D CT Image Simulation-based Analysis of Threshold Setting for Pulmonary Nodule Volumetric Evaluation
  • ハイ ケッセツ タイセキ ヒョウカ ノ タメ ノ ノウド イキチ セッテイ ニ カンスル 3ジゲン CT ガゾウ シミュレーション カイセキ

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We simulated three-dimensional (3D) computed tomography images from the 3D object functions of ideal spheres, assuming solitary pulmonary nodules, by using the point spread function measured in a scanner. On the simulated images, we calculated the sphere volumes with a simple threshold technique in which the relationship between the threshold and the volume was analyzed. First, we confirmed that the results obtained by the simulation agreed well with those obtained by the experiment using a sphere phantom. Subsequently, we determined the threshold (defined as Tʹ) so that the sphere volume in simulated images was equal to its object function (true volume). We quantitatively determined that the Tʹ changed with the object diameter while maintaining a constant density in the object, and Tʹ depended on the reconstruction kernel, slice thickness and slice location. When the half maximum of the sphere density in the simulated image, which corresponds to the half maximum in a well known term full-width at half maximum (FWHM), was used as the threshold, the accuracy for the obtained volume fluctuated in relation to the above Tʹ change. Our simulation technique and present results will be effective for basic research on 3D nodule analysis.

収録刊行物

  • 医学物理

    医学物理 30 (2), 39-48, 2010

    公益社団法人　 日本医学物理学会

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