小腸移植における非破壊的水素含有処理による臓器保存液の開発

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  • The development of preservation solution using nondestructive hydrogen dissolver for intestinal transplantation

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Ischemia reperfusion injury(IRI)during intestinal transplantation(ITx)causes bacterial translocation and leads to morbidity and mortality. Hydrogen is noted as an antioxidant material, which can reduce IRI. Thus, we examined the effect of hydrogen-rich solution by intraluminal injection in intestinal IRI model of rats. Intraluminal injection of hydrogen-rich solution significantly reduced oxidative stress and decreased intestinal IRI. Towards clinical application, we are going to proceed to swine ITx model by using nondestructive hydrogen dissolver for intestinal graft preservation. Graft injury was ameliorated by this preservation method in spite of 18-24 hours of cold ischemic time. Hydrogen-rich solution could be a next-generation and promising preservation solution for clinical ITx.

収録刊行物

  • Organ Biology

    Organ Biology 20 (2), 142-147, 2013

    一般社団法人　日本臓器保存生物医学会

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