Development of a local light stimulation device integrated with micro electrode array

  • UENO Hidetaka
    Division of Mechanical Science and Technology, Gunma University
  • KOMAI Shoji
    Division of Biomedical Science, Nara Institute of Science and Technology
  • TERAO Kyohei
    Department of Intelligent Mechanical System Engineering, Kagawa University
  • TAKAO Hidekuni
    Department of Intelligent Mechanical System Engineering, Kagawa University
  • SHIMOKAWA Fusao
    Department of Intelligent Mechanical System Engineering, Kagawa University
  • KOTERA Hidetoshi
    Department of Microengineering, Kyoto University
  • SUZUKI Takaaki
    Division of Mechanical Science and Technology, Gunma University

Abstract

<p>In this paper, we propose a simple plasma-less fabrication and integration method for biomicrodevice applications. For optogenetics, microlenses and pinholes irradiating local sight of biological tissue with focused visible light and electrodes measuring a biological electropotential are integrated by using organic materials such as polymer. The proposed fabrication method consists of photolithography and wet-etching process only. The shape of fabricated microlenses measured by a white light interferometer was the diameter of 111.5 μm, the depth of 45.5 μm, and the focal length 320 μm. The impedance of Platinum black electroplated on the fabricated electrode pads was reduced to 200 kΩ. As the results, it is succeeded to integrate electrode pads, microlenses and pinholes without plasma etching process. The fabricated dish is assembled with a light irradiation device having two LEDs. By the light irradiation test, the fabricated dish is expected to be utilized in a variety of neuroscience researches. By the test for cytotoxicity, it is succeeded to create neural network on the fabricated dish.</p>

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