THE FRONTIERS OF THE PATHOPHYSIOLOGY, DIAGNOSIS, AND TREATMENT OF KNEE OSTEOARTHRITIS

DOI Web Site Web Site 3 Citations 22 References Open Access
  • ISHIJIMA MUNEAKI
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL SPORTOLOGY CENTER, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE
  • KUBOTA MITSUAKI
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • NING LIANG
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE RESEARCH INSTITUTE FOR DISEASE OF OLD AGE, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE
  • LIU LIZU
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE SPORTOLOGY CENTER, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE
  • KANEKO HARUKA
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • FUTAMI IPPEI
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • SADATSUKI RYO
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • HANEDA SHINNOSUKE
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • YUSUP ANWARJAN
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • SHIMURA YUKIO
    DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO TOKYO KOTO GERIATRIC MEDICAL CENTER, JUNTENDO UNIVERSITY
  • HIRASAWA ERI
    RESEARCH INSTITUTE FOR DISEASE OF OLD AGE, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE
  • SAITA YOSHITOMO
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • TAKAZAWA YUJI
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • IKEDA HIROSHI
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL
  • KUROSAWA HISASHI
    DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO TOKYO KOTO GERIATRIC MEDICAL CENTER, JUNTENDO UNIVERSITY
  • KANEKO KAZUO
    DEPARTMENT OF MEDICINE FOR ORTHOPAEDICS AND MOTOR ORGAN, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE DEPARTMENT OF ORTHOPAEDIC SURGERY, JUNTENDO UNIVERSITY HOSPITAL SPORTOLOGY CENTER, JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE

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Other Title
  • 変形性膝関節症の病態・診断・治療の最前線
  • ヘンケイセイ シツカンセツショウ ノ ビョウタイ ・ シンダン ・ チリョウ ノ サイゼンセン

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Locomotive syndrome refers to conditions under which the elderly receive care services, or have high-risk conditions under which they may soon require care services, due to locomotive organ disorders. Knee osteoarthritis (OA) is one of the representative diseases strongly associated with locomotive syndrome. While OA is a disease that primarily results in the degeneration and destruction of articular cartilage, other joint structures, such as the meniscus, subchondral bone, and synovium, are also affected, which results in disability in the activities of daily living. Although the gold standard for assessing joint damage is still plain radiography, biomarkers and magnetic resonance imaging (MRI) are candidates that can detect and monitor joint structures precisely. Given the lack of disease-modifying drugs (DMORDs) for the treatment of knee OA, there is a strong need for treatments of knee pain. Recently, opioids have become available for the treatment of knee OA. For surgical treatment, while endoscopic surgery should be performed for limited cases with meniscal catching or rocking, joint replacement surgeries (TAK or UKA) are associated with excellent long-term outcomes. In addition, high tibial osteotomy (HTO) is also recommended because of the development of a fixation device with stable mid-term outcomes. Therefore, surgical treatment should be considered positively for patients with end-stage knee OA. Owing to the lack of systematic treatment guidelines for knee OA, evidence-based systematic treatment guidelines for knee OA are required.

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