PATHOLOGICAL THERAPEUTIC EFFECTS OF PREOPERATIVE SYSTEMIC CHEMOTHERAPY ASSOCIATED WITH BIOMARKERS FOR PRIMARY BREAST CANCER

DOI Web Site Web Site 27 References
  • SENUMA KOJI
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • MIURA KAYO
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • MIURA HIROYOSHI
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • HORIMOTO YOSHIYA
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • NAKAI KATSUYA
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • SHIMADA SATOKO
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • ARAKAWA ATSUSHI
    DEPARTMENT OF HUMAN PATHOLOGY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • SONOUE HIROSHI
    DEPARTMENT OF HUMAN PATHOLOGY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE
  • SAITO MITSUE
    DEPARTMENT OF BREAST AND ENDOCRINE SURGERY, JUNETNDO UNIVERSITY FACULTY OF MEDICINE

Bibliographic Information

Other Title
  • 術前化学療法を施行した原発性乳癌の組織学的治療効果と関連因子の検討
  • ジュツゼン カガク リョウホウ オ シコウ シタ ゲンパツセイ ニュウガン ノ ソシキガクテキ チリョウ コウカ ト カンレン インシ ノ ケントウ

Search this article

Description

Objective : Preoperative systemic chemotherapy (PSC) has become part of the standard treatment for locally advanced primary breast cancer. The aim of this study was to examine the efficacy of PSC for locally advanced primary breast cancer regarding the association of pathological response with certain biomarkers. Materials : The records of patients treated for breast cancer at Juntendo University Hospital from January 2006 to August 2008 were reviewed from a prospectively collected database. A total of 144 patients diagnosed with primary breast cancer, whose specimens were investigated by immunostaining, underwent PSC during this period. Methods : A comparison was made between the pathological complete response (pCR) and hormonal receptor, human epidermal growth factor receptor type 2 (HER2), Ki-67 and topoisomerase IIα (Topo IIα). The correlations of HER2 with Topo IIα, hormonal receptor and intrinsic subtypes were also studied. Results : pCR was achieved in 16 cases (11%). The rate of pCR was significantly higher in hormonal status-negative cases than in hormonal status-positive ones. pCR in HER2-positive cases, however, showed no significant difference compared with that in negative ones. The rate of pCR was significantly higher in high-Ki-67 cases than in low-Ki-67 ones. pCR showed no significant difference between the high-Topo IIα and low-Topo IIα cases. No correlation was observed in HER2 with Topo IIα and hormonal status. In terms of intrinsic subtype classification, pCR in HER2 type and triple-negative type (i. e. estrogen-negative, progesterone-negative and HER2-negative) was significantly higher in luminal A/ B types. Conclusions : We showed that the efficacy of PSC was affected by not only hormonal-negative and high-Ki-67 status, but also HER2 type and triple-negative type.

Journal

References(27)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top