A Case of IgG4-Related Disease Admitted with CRP Elevation of Unknown Origin

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  • INUI AKIHIRO
    Department of General Medicine, Juntendo University Faculty of Medicine
  • NAITO TOSHIO
    Department of General Medicine, Juntendo University Faculty of Medicine

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Abstract

<p> We describe the case of a 32-year-old man with C-reactive protein (CRP) elevation of unknown origin who was transferred to Juntendo University Hospital on suspicion of systemic viral infection. Whole-body computed tomography (CT) showed enlargement of the para-aortic, common iliac and axillary lymph nodes. Laboratory data showed elevated levels of immunoglobulin (Ig)G4. Axillary lymph node biopsy was performed to investigate suspected IgG4-related disease, revealing marked infiltration of IgG4-positive plasma cells. Various imaging modalities and laboratory tests have recently become available. However, most neoplastic diseases need invasive testing such as biopsy to reach a definitive diagnosis. Clinicians should not hesitate to obtain pathological specimens to definitively diagnose patients with suspected neoplastic disease.</p>

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