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- Takamori Yasushi
- Research and Development Center, BioMedical Laboratories, Inc. Human Gene Sciences Center, Tokyo Medical and Dental University
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- Ogawa Kazuyuki
- Research and Development Center, BioMedical Laboratories, Inc.
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- Nagata Kinya
- Research and Development Center, BioMedical Laboratories, Inc.
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- Takano Shoichi
- Research and Development Center, BioMedical Laboratories, Inc.
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- Nakamura Masataka
- Human Gene Sciences Center, Tokyo Medical and Dental University
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説明
Exogenously added granulysin was reported to kill mammalian target cells. The sites of actions and molecular mechanisms of granulysin in target cell killing, however, are presently unclear. We here examine the effects of granulysin with the target HeLa cells transiently expressed with GFPfused 9 kDa granulysin. Endogenously expressed GFP-fused granulysin was preferentially localized in the nucleus and induced apoptotic cell death accompanying with phosphatidylserine translocation and nuclear condensation in a caspase-independent manner. These results suggest that granulysin enters the nucleus of target cells and induces apoptosis.
収録刊行物
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- Journal of Medical and Dental Sciences
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Journal of Medical and Dental Sciences 52 (1), 1-7, 2005
国立大学法人 東京医科歯科大学
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詳細情報 詳細情報について
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- CRID
- 1390001205517397120
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- NII論文ID
- 110001065270
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- NII書誌ID
- AA12028964
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- ISSN
- 21859132
- 13428810
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可