Regulatory Mechanism of Ameloblast Differentiation

YAMADA Aya, IWAMOTO Tsutomu, NAKAMURA Takashi, FUKUMOTO Satoshi

doi:10.11411/jspd.48.3_374

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Other Title

エナメル芽細胞の分化制御機構

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Abstract

Tooth organs develop through the sequential reciprocal signaling interaction between ectodermalderived epithelial cells and cranial neural crest-derived mesenchymal cells. In recent advances in tissue engineering technology and developmental biology, a partial tooth regeneration has been demonstrated by using embryonic mouse dental epithelial and mesenchyme cells. However, no technology of tooth reconstruction has been identified to regulate tooth morphogenesis possessing positional characters of original tooth shape and size for its function. In this study, we focus on the roles of ameloblastin, one of the enamel matrix proteins, in dental epithelial cell differentiation into ameloblast and enamel formation. Ameloblastin regulates not only ameloblast proliferation and differentiation,but also enamel formation. In addition, ameloblastin controls the cell polarity of ameloblast, which go through multiple stages of differentiation to orchestrate enamel formation. The enamel epithelium does not exist in adult teeth, and currently there are not readily available sources of dental epithelial cells. This limitation, along with a lack of knowledge on mechanisms guiding the formation of enamel, impacts our capacity to develop strategies for the repair and regeneration of enamel.

Journal

The Japanese Journal of Pediatric Dentistry

The Japanese Journal of Pediatric Dentistry 48 (3), 374-380, 2010

Japanese Society of Pediatric Dentistry

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Details 詳細情報について

CRID: 1390001205519829120

NII Article ID: 10027489970

NII Book ID: AN00116228

DOI: 10.11411/jspd.48.3_374

ISSN: 21865078; 05831199

Web Site: https://search.jamas.or.jp/link/ui/2010330618

Text Lang: ja

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JaLC
CiNii Articles
KAKEN

Abstract License Flag: Disallowed

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