中咽頭癌肺転移症例に対するTS-1使用経験

DOI Web Site 被引用文献2件 参考文献16件

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タイトル別名
  • The Experience of Using TS-1 for Oropharyngeal Cancer with Pulmonary Metastases
  • チュウ イントウガン ハイ テンイ ショウレイ ニ タイスル TS 1 シヨウ ケイケン

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We report a case of pulmonary metastases of oropharyngeal cancer that responded well to chemotherapy using TS-1. The patient was a 58-year-old man who underwent concurrent chemoradiotherpy consisting of 2 courses of chemotherapy and radiation therapy at 60 Gy as first-line therapy for oropharyngeal cancer (T2N2bM20, stage IVa). The primary tumor and the metastatic lesions in cervical lymph nodes showed a complete response. Four months later, multiple metastases to the lung were noted, for which TS-1 was administered. One course consisted of consecutive administration of TS-1 for 28 days and withdrawal for 14 days. After the completion of 3 courses, the pulmonary metastases could not be detected in chest radiographs. Although there were recurrences of the pulmonary and liver metastases after 5and 2 courses of treatment respectively, medication could be continued for 18 months following the occurrence of the pulmonary metastases. Adverse effects were limited to mild anorexia and no hospitalization was required during the TS-1 treatment. It is suggested that the administration of TS-1 enhanced both the survival time and the quality of life in this patient.

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