ANTITUMOR ACTIVITY OF 4(OR 5)-AMINOIMIDAZOLE-5(OR4)-CARBOXAMIDE DERIVATIVES

  • HANO Kotobuki
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
  • AKASHI Akira
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
  • YAMAMOTO Itaru
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
  • NARUMI Shigehiko
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University
  • HORII Zen-ichi
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Osaka University
  • NINOMIYA Ichiya
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Osaka University

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Description

A series of 4-alkyltriazeno-imidazole (or -triazole)-5-carboxamides were tested for their growth-inhibitory effect on Ehrlich tumor. Of the compounds tested, 4-dimethyltri-azenoimidazole-5-carboxamide and 4-dipropyltriazeno-imidazole (or -traizole)-5-carboxamide were found to be the most effective inhibitor of solid tumor. Except for 4-diazoimidazole-5-carboxamide, none of the compounds tested had any effect on the ascites form.

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