CARCINOGENICITY OF 2-(2-FURYL)-3-(5-NITRO-2-FURYL) ACRYLAMIDE (AF-2) FED TO FEMALE SPRAGUE-DAWLEY RATS
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- COHEN Samuel M.
- First Department of Pathology, Nagoya City University Medical School
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- ICHIKAWA Masataka
- Faculty of Pharmaceutical Sciences, Kumamoto University Division of Clinical Oncology, Department of Human Oncology, University of Wisconsin Center for Health Sciences
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- BRYAN George T.
- Division of Clinical Oncology, Department of Human Oncology, University of Wisconsin Center for Health Sciences
Bibliographic Information
- Other Title
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- Carcinogenicity of 2 2 Furyl 3 5 nitro
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Abstract
The carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet at a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1g (41.6mmol) per rat during the 46 weeks of the experiment. Weight gain of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52±12 (SD) weeks compared to 65±5 weeks for the unmedicated controls (P<0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated control rats had single fibroadenomas of the breast.
Journal
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 68 (4), 473-476, 1977
The Japanese Cancer Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001205529176320
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- NII Article ID
- 130006409659
- 40000529001
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- NII Book ID
- AN00045888
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- NDL BIB ID
- 1838433
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- ISSN
- 0016450X
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed