INDUCTION OF TUMORS OF PERIPHERAL NERVOUS SYSTEM IN FEMALE DONRYU RATS BY CONTINUOUS ORAL ADMINISTRATION OF 1-METHYL-1-NITROSOUREA
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- OGIU Toshiaki
- Department of Chemical Pathology, National Institute of Hygienic Sciences
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- NAKADATE Masahiro
- Department of Synthetic Chemistry, National Institute of Hygienic Sciences
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- FURUTA Kyoko
- Department of Chemical Pathology, National Institute of Hygienic Sciences
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- MAEKAWA Akihiko
- Department of Chemical Pathology, National Institute of Hygienic Sciences
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- ODASHIMA Shigeyoshi
- Department of Chemical Pathology, National Institute of Hygienic Sciences
Bibliographic Information
- Other Title
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- Induction of Tumors of Peripheral Nervo
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Abstract
Groups 1, 2, and 3 of female Donryu rats were given continuously 400, 200, or 100ppm solution of 1-methyl-1-nitrosourea (MNU) as their drinking water. The incidence of neurogenic tumors was 12/27 (44%), 30/33 (91%), and 33/36 (92%) in Groups 1, 2, and 3, respectively. Among the neurogenic tumors, neurinomas developing from the spinal nerve roots were the most frequent. In addition, tumors of the digestive tract were found in 12, 1, and 2 rats in Groups 1, 2, and 3, respectively, and tumors in hematopoietic tissues developed in 6 rats. Tumors in other organs were infrequent.
Journal
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 68 (4), 491-498, 1977
The Japanese Cancer Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001205529245952
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- NII Article ID
- 130006409626
- 40000529000
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- NII Book ID
- AN00045888
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- NDL BIB ID
- 1838432
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- ISSN
- 0016450X
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed