EFFECT OF 1-(2-CHLOROETHYL)-3-(β-D-GLUCOPYRANOSYL)-1-NITROSOUREA ON EXPERIMENTAL TUMORS

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  • Effect of 1 2 Chloroethyl 3 ベータ D gluco

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Abstract

A newly synthesized water-soluble nitrosourea derivative, 1-(2-chloroethyl)-3-(β-D-glucopyranosyl)-1-nitrosourea (GANU; NSC-254157) has marked activities against experimental tumors such as lymphoid leukemia L-1210, ascites sarcoma-180, ascites hepatoma AH-130, and Walker carcinosarcoma-256. A single intraperitoneal injection of the compound is more effective than successive injections on the L-1210 system.<br>An especially interesting point is that both the single intraperitoneal and single oral administrations 2 days after tumor implantation showed a high effectiveness. In addition, growth of the mammary adenocarcinoma transplanted subcutaneously on the back of mice was also considerably suppressed by successive intraperitoneal injections of the compound.

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