CHRONIC TOXICITY OF 2-(2-FURYL)-3-(5-NITRO-2-FURYL) ACRYLAMIDE (AF-2) IN MICE, WITH SPECIAL REFERENCE TO CARCINOGENICITY IN THE FORESTOMACH
-
- YOKORO Kenjiro
- Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University
-
- KAJIHARA Hiroki
- Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University
-
- KODAMA Yuso
- Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University
-
- NAGAO Kenji
- Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University
-
- HAMADA Katsutomo
- Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University
-
- KINOMURA Aiko
- Department of Pathology, Research Institute for Nuclear Medicine and Biology, Hiroshima University
Bibliographic Information
- Other Title
-
- Chronic Toxicity of 2 2 Furyl 3 5 nitro
Search this article
Abstract
Chronic toxicity of 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (AF-2), which had been widely used in Japan as a food additive, was studied in both sexes of ICR/JCL mice by feeding a diet containing AF-2 in a concentration of 0.4% or 0.08%. The experiments confirmed its definite carcinogenicity in the forestomach, with dose dependency; more than 70% of mice fed the higher dose developed tumors, the majority of which were squamous cell carcinomas with metastatic growths, whereas, with a lower dose, fewer tumors occurred, following a longer latent period. In addition, possible leukemogenicity was suggested by a higher incidence in AF-2-fed females (10.8%) over that in control females (3.2%). The development of non-neoplastic lesions in the liver and kidneys, and of amyloidosis in various organs was also observed in some of AF-2-fed mice.
Journal
-
- GANN Japanese Journal of Cancer Research
-
GANN Japanese Journal of Cancer Research 68 (6), 825-828, 1977
The Japanese Cancer Association
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390001205529326080
-
- NII Article ID
- 40000528964
- 130006409780
-
- NII Book ID
- AN00045888
-
- NDL BIB ID
- 1917534
-
- ISSN
- 0016450X
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
-
- Abstract License Flag
- Disallowed