EFFECT OF VARIOUS FACTORS ON THE INDUCTION OF LIVER TUMORS IN ANIMALS BY QUINOLINE
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- SHINOHARA Yoshitaka
- First Department of Pathology, Nagoya City University Medical School
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- OGISO Tadashi
- First Department of Pathology, Nagoya City University Medical School
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- HANANOUCHI Motoo
- First Department of Pathology, Nagoya City University Medical School
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- NAKANISHI Keisuke
- First Department of Pathology, Nagoya City University Medical School
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- YOSHIMURA Takashi
- First Department of Pathology, Nagoya City University Medical School
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- ITO Nobuyuki
- First Department of Pathology, Nagoya City University Medical School
Bibliographic Information
- Other Title
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- Effect of Various Factors on the Induct
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Abstract
Tumorigenic effect of a diet containing quinoline on the liver of various animals and the synergistic or antagonistic effect by other chemicals on quinoline hepatocarcinogenesis in rats were examined. It was concluded that 4, 4'-diaminodi-phenylmethane (0.1%) and 3-methylcholanthrene (0.0067%) had a significant inhibitory effect on liver carcinogenesis due to quinoline in rats, but 1-naphthyl isothiocyanate (0.06%) and p-hydroxypropiophenone (1.0%) had no inhibitory effect in the present observations. Transmission electron-microscopic study demonstrated the fine structure of vascular tumors induced by quinoline. On the other hand, it was found that quinoline induced liver tumors in both sexes of mice and rats but not in hamsters or guinea pigs. Male rats were more susceptible than females to the tumorigenic action of quinoline, and mice showed the least susceptibility. Histological changes in the liver of rats or mice induced by quinoline were classified as hemangioendotheliomas or hemangiosarcomas and hepatocellular carcinomas. Several rats treated with quinoline had hemangiosarcomatous metastatic foci in the lung.
Journal
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 68 (6), 785-796, 1977
The Japanese Cancer Association
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Details 詳細情報について
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- CRID
- 1390001205529330816
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- NII Article ID
- 130006409782
- 40000528952
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- NII Book ID
- AN00045888
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- NDL BIB ID
- 1917522
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- ISSN
- 0016450X
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed