EFFECT OF N-(3, 5-DICHLOROPHENYL)SUCCINIMIDE ON THE HISTOLOGICAL PATTERN AND INCIDENCE OF KIDNEY TUMORS INDUCED BY STREPTOZOTOCIN IN RATS
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- SHINOHARA Yoshitaka
- First Department of Pathology, Nagoya City University Medical School
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- MIYATA Yukitada
- First Department of Pathology, Nagoya City University Medical School
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- MURASAKI Gen'i
- First Department of Pathology, Nagoya City University Medical School
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- NAKANISHI Keisuke
- First Department of Pathology, Nagoya City University Medical School
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- YOSHIMURA Takashi
- First Department of Pathology, Nagoya City University Medical School
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- ITO Nobuyuki
- First Department of Pathology, Nagoya City University Medical School
Bibliographic Information
- Other Title
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- Effect of N 3 5 Dichlorophenyl succinim
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Abstract
The effect of the nephrotoxic substance, N-(3, 5-dichlorophenyl) succinimide, on the histological pattern and incidence of kidney tumors induced by streptozotocin in rats was studied. In groups administered streptozotocin alone or in combination with nicotinamide, the histological pattern and the incidence of kidney tumors in rats were similar; renal cell tumors developed in 1 of 9 rats (11.1%) and in 2 of 17 rats (11.8%), respectively. However, post-treatment with N-(3, 5-dichlorophenyl) succinimide increased the induction of epithelial tumors by streptozotocin, and embryonal cell tumors were also induced nearly as frequently. Administration of nicotinamide alone did not result in the development of kidney tumors.
Journal
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 68 (4), 397-404, 1977
The Japanese Cancer Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001205529842176
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- NII Article ID
- 130006409635
- 40000528999
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- NII Book ID
- AN00045888
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- NDL BIB ID
- 1838431
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- ISSN
- 0016450X
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed