DIAGNOSIS OF CANCER BY RADIOIMMUNOASSAY OF MUSCLE TYPE ALDOLASE

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  • 浅香 正博
    Third Department of Internal Medicine, School of Medicine, Hokkaido University
  • 長瀬 清
    Third Department of Internal Medicine, School of Medicine, Hokkaido University
  • 白石 忠雄
    Third Department of Internal Medicine, School of Medicine, Hokkaido University
  • 宮崎 保
    Third Department of Internal Medicine, School of Medicine, Hokkaido University

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タイトル別名
  • Diagnosis of Cancer by Radioimmunoassay

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A specific radioimmunoassay was developed for the quantification of human muscle type aldolase (M-ALD) in human serum. The method utilized the double antibody radioimmunoassay technique using radioiodinated M-ALD, chicken antibody to M-ALD and rabbit antibody to chicken IgG. The serum M-ALD values of 41 normal healthy subjects ranged from 130 to 210ng/ml, average 171±39ng/ml. In 76 noncancer hospital patients, excluding patients with muscle diseases, the serum M-ALD values ranged from 125 to 220ng/ml, average 164±52ng/ml. In contrast, 129 cancer patients had high serum M-ALD values of 586±926ng/ml, ranging from 85 to 5, 800ng/ml. Eighty-six percent of the cancer patients showed serum M-ALD concentrations over the normal range. The measurement of M-ALD values in the serum of patients by radioimmunoassay may be a valuable laboratory test in the diagnosis and follow-up of cancer patients.

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