ANALYSIS OF CELL SURFACE ANTIGEN ON NEOPLASTIC LYMPHOCYTES BY THE USE OF ANTI-HUMAN BRAIN SERUM

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  • 河田 誠
    Department of Obstertrics and Gynecology, School of Medicine, Chiba University
  • 大森 景文
    Department of Obstertrics and Gynecology, School of Medicine, Chiba University
  • 田辺 恵美子
    Department of Dermatology, School of Medicine, Chiba University
  • 奥村 康
    Department of Immunology, Faculty of Medicine, University of Tokyo
  • 高見沢 裕吉
    Department of Obstertrics and Gynecology, School of Medicine, Chiba University
  • 多田 富雄
    Department of Immunology, Faculty of Medicine, University of Tokyo

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タイトル別名
  • Analysis of Cell Surface Antigen on Neo

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Cell surface antigens on neoplastic lymphoid cells of T cell lineage were analyzed with a fluorescence-activated cell sorter (FAGS-II) by utilizing rabbit antisera raised against human brain tissue (anti-Br) and fetal thymocytes (anti-Ty). Both before and after extensive absorption with normal peripheral blood lymphocytes (PBL), the anti-Br antiserum was capable of staining neoplastic lymphoid cells from patients with Sézary syndrome, mycosis fungoides, thymoma, and chronic lymphocytic leukemia. The absorption of anti-Ty with normal PBL, however, resulted in loss of the ability to stain these neoplastic cells. The anti-Br preabsorbed with normal PBL was found to stain normal bone marrow cells and neoplastic myeloid cells but not fetal thymocytes. It is suggested that the absorbed anti-Br is capable of detecting differentiation antigens present on immature hematopoietic cells in the bone marrow, which would be anomalously expressed on neoplastic lymphoid cells of T cell lineage.

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