Is hedgehog high sensitive to xenobiotics? Low metabolism enzyme activities observed in African hedgehog (Atalerix albiventris)
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- SAENGTIENCHAI Aksorn
- Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University Kasetsart University
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- IKENAKA Yoshinori
- Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University North-West University
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- SAM Nesta Bortey
- Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University
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- JERMNARK Usuma
- Kasetsart University
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- MIZUKAWA Hazuki
- Graduate School of Veterinary Medicine, Hokkaido University
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- NAKAYAMA Shouta M.M.
- Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University
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- ISHIZUKA Mayumi
- Laboratory of Toxicology, Graduate School of Veterinary Medicine, Hokkaido University
Bibliographic Information
- Other Title
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- ハリネズミは化学物質高感受性種？African hedgehog (Atalerix albiventris)で観察された低薬物代謝能
Abstract
African hedgehog, Atalerix albiventris, is a spiny mammal which becomes famous exotic pet in many counties. In order to elucidate xenobiotic metabolisms ability of hedgehogs, pyrene, one of the typical polycyclic aromatic hydrocarbon were exposed. From in vivo exposure study, pyrene was biotransformed to glucuronide and sulfate conjugates such as pyrene-1-glucuronide, pyrene-1-sulfate, and pyrenediol-sulfate and excreted to urine. Pyrene-1-glucuronide was main metabolite and limited excretion of sulfate conjugates were observed. Based on the results of in vivo exposure study, in vitro enzymatic kinetic experiments were performed by using various substrate and compare to rat and pig. Enzyme efficiency of cytochrome P450 (CYP) mediated Ethoxyresorufin O-deethylase activity, and warfarin 4'-, 6-, and 8-hydroxylation activity in hedgehogs were lower than that of rats. Furthermore, UDP-glucuronosyltransferase activities in hedgehogs were also lower Km than that of rats. Interestingly, the enzymatic efficiency of sulfation in hedgehogs was significantly lower than that of rats, whereas hedgehogs had similar sulfation ability as in pigs. Sulfation of hedgehogs may be limit activity in xenobiotic metabolism.
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 43.1 (0), P-237-, 2016
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390001205546779904
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- NII Article ID
- 130005260768
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed