Synthesis and sutractural analysis of Bismuth Subsalicylate(BSS) derivatives

DOI

Bibliographic Information

Other Title
  • サリチル酸ビスマス(BSS)誘導体の合成及び構造解析

Description

Bismuth subsalicylate (BSS), commonly marketed as colloidal suspensions under the commercial names of "Pepto-Bismol", is a drug regularly used for therapeutic treatment of gastric anger. BSS has been effective in the treatment and eradication of Helicobacter pylori, the bacterium linked to gastritis and ulceration implicated in the development of gastric cancer.<BR> However, the biotic activity mechanism and structure of BSS is unexplained in detail because of the typical insolubility of this compound. Its high degree of insolubility has made the definitive determination its nature extremely difficult.<BR> In this work, we improved solubility of BSS by substitution on the salicylic scaffold.

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Keywords

Details 詳細情報について

  • CRID
    1390001205556565248
  • NII Article ID
    130004728737
  • DOI
    10.11494/kisoyuki.2009.0.130.0
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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