<I>In vivo</I> evaluation of porous beta-tricalcium phosphate ceramics with bi-model pore structure using a transgenic-cloned pig expressing red fluorescent protein, Kusabira-Orange

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Other Title
  • クサビラオレンジ蛍光遺伝子を導入したブタを用いた二極化した細孔構造を備えたβ-リン酸三カルシウム多孔体の<I>in vivo</I>評価

Description

Porous beta-tricalcium phosphate (beta-TCP) ceramics with bi-model pore structure were fabricated by firing calcium-phosphate fiber compacts mixed with carbon beads. We examined the biocompatibility of the resulting porous beta-TCP ceramics using a transgenic-cloned pig carrying a gene for the red fluorescent protein, humanized Kusabira-Orange (huKO). The porous beta-TCP ceramics were implanted into tibia of a transgenic-cloned pig for 6 weeks, and then the frozen tissue sections were prepared for histological evaluations. The newly-formed bone was present inside pores of the porous beta-TCP ceramics. We concluded that the porous beta-TCP ceramics with bi-model pore structure have an excellent osteoconductivity.

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Details 詳細情報について

  • CRID
    1390001205618269952
  • NII Article ID
    130006976691
  • DOI
    10.14853/pcersj.2011s.0.254.0
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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