A Novel Strategy for Comprehensive Prediction of Gene Function by Integration of Transcriptomics and Metabolomics
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- Hirai Masami
- RIKEN Plant Science Center
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- Kanaya Shigehiko
- 奈良先端大・情報科学
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- Sawada Yuji
- RIKEN Plant Science Center
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- Tohge Takayuki
- RIKEN Plant Science Center
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- Kusano Miyako
- RIKEN Plant Science Center
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- Hukushima Atsushi
- RIKEN Plant Science Center
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- Akiyama Kenji
- RIKEN Plant Science Center
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- Sakurai Tetsuya
- RIKEN Plant Science Center
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- Shimada Yukihisa
- RIKEN Plant Science Center
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- Goda Hideki
- RIKEN Plant Science Center
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- Obayashi Takeshi
- 千葉大院・薬 CREST・JST
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- Yano Mitsuru
- 千葉大院・薬
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- Sugiyama Kenjiro
- かずさDNA研・NEDO基盤研
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- Sakurai Nozomu
- かずさDNA研・NEDO基盤研
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- Suzuki Hideyuki
- かずさDNA研・NEDO基盤研
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- Shibata Daisuke
- かずさDNA研・NEDO基盤研
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- Saito Kazuki
- RIKEN Plant Science Center
Bibliographic Information
- Other Title
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- トランスクリプトミクスとメタボロミクスの統合による包括的遺伝子機能予測
Abstract
Gene expression profiles of Arabidopsis under various conditions and in various organs are available in public databases. Analysis of co-expressed genes using such microarray data enables us to predict gene function comprehensively. In our previous study on integration of transcriptome and metabolome data of sulfur-starved Arabidopsis, we were able to identify the genes encoding the enzymes involved in particular metabolic pathways. In a similar way, we can predict the genes encoding transcriptional factors involved in particular metabolic pathways. The genes which co-express in all experimental conditions are considered to be regulated by a single regulatory mechanism, while the genes which co-express under particular conditions are considered to be regulated by several different mechanisms. Such a comprehensive analysis of all available microarray data enables us to predict regulatory networks. Collection of metabolite profiles under various conditions and integrated analysis with gene expression profiles is useful for precise prediction of gene function.
Journal
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- Plant and Cell Physiology Supplement
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Plant and Cell Physiology Supplement 2006 (0), 104-104, 2006
The Japanese Society of Plant Physiologists
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Details 詳細情報について
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- CRID
- 1390001205628886272
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- NII Article ID
- 130006989226
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed