Interaction studies of COP9 signalosome subunit 1 and SAP130 suggest a novel CSN function

DOI

Bibliographic Information

Other Title
  • COP9シグナロソームとSAP130の相互作用解析

Abstract

The COP9 signalosome (CSN) is a nuclear protein complex essential for plant and animal development. It has been shown that the N terminus of CSN1 (CSN1N) represses transcription of JNK1 in the JNK1/SAPK signaling pathway. Inhibitory studies suggested that this repression was different from the known proteasome-mediated proteolysis. To further understand this mechanism, interacting proteins (NBPs) directly binding to CSN1N were purified from mammalian cells. SAP130, one of NBPs, is known to be involved in mRNA splicing. SAP130 is a subunit of the SF3b complex that associates with the U2 snRNP complex and the STAGA complex, suggesting that CSN is involved in post-transcriptional regulation. <br> To characterize this novel function of CSN in the plant kingdom, we have identified the homolog of SAP130 in Arabidopsis (AtSAP130). AtSAP130 was encoded by two genes mapping to chromosome 3 producing identical protein. Here, we will discuss the interaction of CSN1N and AtSAP130.

Journal

Details 詳細情報について

  • CRID
    1390001205628957440
  • NII Article ID
    130006989315
  • DOI
    10.14841/jspp.2006.0.045.0
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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