蛍光性ペプチドの合成を目的とした新規蛍光アミノ酸の開発研究
書誌事項
- タイトル別名
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- Development of New Fluorescent Amino Acid for Synthesis of Fluorescent Peptide
説明
We have developed new fluorescent amino acids which were easily synthesized by condensation of the fluorescent molecule and protected amino acids, which were ornithine and serine. Fluorescent molecule was prepared from oxalacetic acid diethyl ester and N,N-dimethylphenylenediamine by 3 steps. Protected amino acids were prepared by 2 and 5 steps from commercially available ornithine and serine derivatives, respectively. With the increase of solvent polarity, the emission spectra of both fluorescent amino acids clearly shifted from 430 nm to 500 nm. Both of Fmoc-protected fluorescent amino acids could be converted to fluorescent peptides by solid-phase synthesis.
収録刊行物
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- 反応と合成の進歩シンポジウム 発表要旨概要
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反応と合成の進歩シンポジウム 発表要旨概要 32 (0), 100-100, 2006
日本薬学会化学系薬学部会
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詳細情報 詳細情報について
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- CRID
- 1390001205634168448
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- NII論文ID
- 130006996419
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可