Chemoselective Bromination of Active Methylene Compounds
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- Kirihara Masayuki
- Shizuoka Institute of Science and Technology
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- Ogawa Shiho
- Shizuoka Institute of Science and Technology
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- Okubo Kumiko
- Shizuoka Institute of Science and Technology
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- Yamamoto Junya
- Shizuoka Institute of Science and Technology
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- Hatano Akihiko
- Shizuoka Institute of Science and Technology
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- Monma Yoshinari
- Konica Minolta Chemical Co. Ltd.
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- Shimizu Tomoko
- Konica Minolta Chemical Co. Ltd.
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- Shimosaki Ryuji
- Konica Minolta Chemical Co. Ltd.
Bibliographic Information
- Other Title
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- 活性メチレン化合物の選択的臭素化反応
Abstract
Halogenated active methylene compounds are important synthetic intermediates owing to their high reactivity for the nucleophilic substitution. A number of methods have previously been described in the literature for the haloganation of active methylene compounds, however, most of them have serious disadvantage. We now report the novel chemoselective bromination of active methylene compounds using potassium bromide, hydrogen peroxide and hydrochloric acid. The monobrominated active methylene compounds were quantitatively obtained from the reaction of the active methylene compounds with potassium bromide and hydrogen peroxide in toluene and hydrochloric acid. Ester bonds, amide bonds and aromatic rings were not affected at all under the reaction conditions.
Journal
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- Proceedings of the Symposium on Progress in Organic Reactions and Syntheses
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Proceedings of the Symposium on Progress in Organic Reactions and Syntheses 31 (0), 186-186, 2005
Division of Organic Chemistry, The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001205634649216
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- NII Article ID
- 130006997085
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed