New Aspects of Stetter Reaction and Cross-Benzoin Reaction Catalyzed by Thiazolium Salts
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- Hara Osamu
- Faculty of Pharmacy, Meijo University
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- Nakamura Taiju
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Tamura Tsutomu
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Makino Kazuishi
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Hamada Yasumasa
- Graduate School of Pharmaceutical Sciences, Chiba University
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- Maeba Isamu
- Faculty of Pharmacy, Meijo University
Bibliographic Information
- Other Title
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- チアゾリウム塩が触媒するStetter反応とベンゾイン縮合の新展開
Abstract
Thiazolium-catalyzed reactions consisted with Stetter reaction and benzoin condensation showed us new aspects: 1) formation of quaternary carbon with Stetter reaction and 2) selective cross-benzoin condensation. The construction of quaternary carbon with Stetter reaction was accomplished with the intramolecular reaction using salicylaldehyde derivatives as substrates. This reaction was carried out with good yield under mild conditions. And also this reaction is the first example of the construction of quaternary carbon with Stetter reaction. We also found that the combination of aromatic aldehyde and aliphatic aldehyde is very important for the selective synthesis of desired acyloin product in the thiazolium salts-catalyzed cross-benzoin reaction.
Journal
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- Proceedings of the Symposium on Progress in Organic Reactions and Syntheses
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Proceedings of the Symposium on Progress in Organic Reactions and Syntheses 30 (0), 178-179, 2004
Division of Organic Chemistry, The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001205634953984
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- NII Article ID
- 130006997430
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed