Evaluation of RBE of carbon-ion beams for epithelial thickness on mouse tongues
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- MURAYAMA Chieko
- Tokai University School of Medicine
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- YOSHIKAWA Masanobu
- Tokai University School of Medicine
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- HIRAYAMA Ryoichi
- National Institute of Radiological Science
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- UZAWA Akiko
- National Institute of Radiological Science
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- KOBAYASHI Hiroyuki
- Tokai University School of Medicine
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- FURUSAWA Yoshiya
- National Institute of Radiological Science
Bibliographic Information
- Other Title
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- マウス舌粘膜上皮細胞障害を指標にした炭素イオン線のRBEの評価
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Abstract
To evaluate if D-methionine, the dextro-isomer of the common amino acid L-methionine, can prevent oral mucositis resulting from heavy ion irradiation during treatment for head and neck cancers. For the first study, RBE of carbon-ion beams for epithelial thickness on mouse tongues was evaluated. The head of female C3H mice, 8 weeks old, were irradiated by five fractionated doses of carbon ion beams (290MeV/u) or 150kV X-rays to induce oral mucositis (ulcers on tongue). Six days after the last irradiation, mice were sacrificed. Excised tongues were evaluated macroscopically and micro- scopically. The thickness of the lingual epithelium was measured. The RBE of 6-cm SOBP (290MeV/u) for epithelium on mouse tongues after fractionated doses is 1.82. It was almost the equivalent value as that for gut crypt survivals reported by enormous studies.
Journal
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- The Japan Radiation Research Society Annual Meeting Abstracts
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The Japan Radiation Research Society Annual Meeting Abstracts 2011 (0), 155-155, 2011
The Japanese Radiation Research Society
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Details 詳細情報について
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- CRID
- 1390001205640614400
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- NII Article ID
- 130007000352
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed