Establishment of potential nutritional biomarkers for water-soluble vitamins using urine samples

Fukuwatari Tsutomu

doi:10.20632/vso.87.1_17

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尿を生体指標として利用した水溶性ビタミンの栄養評価法の確立(若手シンポジウム「ビタミン基礎研究の進展を担う若手研究者たち」,<特集>ビタミン基礎研究の進展を担う若手研究者たち(第64回大会若手シンポジウム))
尿を生体指標として利用した水溶性ビタミンの栄養評価法の確立
ニョウオセイタイシヒョウトシテリヨウシタスイヨウセイビタミンノエイヨウヒョウカホウノカクリツ

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Description

Although often used for such purposes, dietary assessments cannot adequately evaluate nutritional status. Alternatively, a biomarker can be an indicator of nutritional status with respect to intake or metabolism of dietary constituents. Recent validation studies have developed the use of urinary compounds as nutritional biomarkers to estimate nutrient intakes, and levels of urinary nitrogen and sodium have been well established as nutritional biomarkers. We have worked to establish levels of urinary water-soluble vitamins as nutritional biomarkers to assess intake, and report the following findings to contribute to the establishment and effectiveness of levels of urinary water-soluble vitamins as potential nutritional biomarkers. Eight of nine water-soluble vitamin levels in 24-hr urine samples increased in a dose-dependent-manner, and were strongly correlated with vitamin intakes under strictly controlled conditions. In contrast, urinary vitamin B_<12> content reflects urine volume but not vitamin B12 intake. The cross-sectional studies show that levels of each urinary water-soluble vitamin, with the exception of vitamin B_<12>, are positively correlated with mean intake over a recent 2-4 day period in free-living children, young and the elderly. These findings suggest that levels of urinary water-soluble vitamins can be used as nutritional biomarkers to assess mean vitamin intakes in these groups.

Journal

VITAMINS

VITAMINS 87 (1), 17-20, 2013

THE VITAMIN SOCIETY OF JAPAN

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