書誌事項
- タイトル別名
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- Neuropathology and pathogenesis of brain damage induced by thiamin deficiency
- チアミン ケツボウ ニ ヨッテ ショウジル チュウスウ シンケイ ショウガイ Wernicke Korsakoff ショウコウグン
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説明
An acute deficiency of thiamin in animals generally leads to focal brain lesions characterized by necrosis and petechial hemorrhage in particular brain regions. In humans, a clinical syndrome based on the brain damage induced by thiamin deficiency is known as Wernicke-Korsakoff syndrome (WKS). To examine the pathogenesis of WKS, rodent models for WKS have been developed and extensively studied. However, the precise mechanism by which thiamin deficiency produces necrotic lesions in particular brain regions is still unclear. In this review, we describe a history of the research on WKS, neuropathological changes induced by thiamin deficiency, and recent advances in understanding the pathogenesis of experimental WKS in the rodent models. Based on the experimental data in the recent literatures, we discuss possible pathways from thiamin deficiency to neuronal death.
収録刊行物
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- ビタミン
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ビタミン 84 (11), 510-516, 2010
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205700831360
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- NII論文ID
- 110007989341
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 10913416
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可