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- 岩田 誠
- 徳島文理大学香川薬学部生体防御学講座
書誌事項
- タイトル別名
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- Regulation of lymphocyte homing and differentiation by vitamin A
- ビタミン A ニ ヨル リンパキュウ ノ ホーミング ト ブンカ ノ セイギョ
この論文をさがす
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Persistent diarrhea is a major cause of infant deaths in developing countries. Vitamin A supplementation significantly reduces the severity of diarrhea and the mortality. The vitamin A metabolite retinoic acid (RA) is an essential factor to imprint gut-homing specificity on lymphocytes. Indeed, vitamin A deficiency causes the depletion of lymphocytes from the small intestinal lamina propria. The gut-related lymphoid organs and the small intestinal lamina propria consist of dendritic cells (DCs) capable of producing RA. RA also contributes to the immune regulation and tolerance by enhancing the transforming growth factor-β-dependent differentiation of inducible Foxp3^+ regulatory T cells and inhibiting that of inflammatory Th17 cells. Thus, the regulation of RA production by gut DCs is critical for immune regulation as well, and mainly depends on ALDH1A2 expression. Its expression is induced mainly by granulocyte-macrophage colony-stimulating factor and other factors constitutively present or induced in the intestinal microenvironment.
収録刊行物
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- ビタミン
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ビタミン 83 (8), 441-452, 2009
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205701115264
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- NII論文ID
- 110007340276
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 10416621
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可