書誌事項
- タイトル別名
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- Development of in vivo evaluation model applied for topical anti-inflammatory agent on the guinea pig skin. : Inhibitory effects of Ascorbate-2-phosphate on croton oil-induced skin inflammatory response
- モルモット ヒフ オ モチイタ エンショウ ヒョウカホウ アスコルビンサン リンサン エステル ニ ヨル クロトンユ ユウキセイ エンショウ ノ ヨクセイ コウカ
この論文をさがす
抄録
In vivo evaluating model is accepted as a powerful tool for determining pharmaceutical effects and safe dosage for clinical use. We established the animal model for evaluating the inflammation caused by reactive oxygen species (ROS). Croton oil (CRO) was topically applied to induce ROS-derived inflammation on the guinea pig skin. Visual inspection of the erythema was performed on 24h after application to evaluate the CRO-induced skin response on a score of one to six. Ascorbate-2-phosphate (AP), ascorbic acid derivative, has been reported to be a potent antioxidant action. To examine its effect on this model, AP was applied topically after CRO application. The inflammation score was significantly reduced by 32-52% of that in the control group. Histological evaluation revealed that AP also decreased the inflammatory thickening and the expression of the oxidative stress marker, 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the skin. These results show the CRO-induced inflammation model developed here is useful tool for evaluating anti-inflammatory and antioxidant effects.
収録刊行物
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- ビタミン
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ビタミン 82 (2), 127-130, 2008
公益社団法人 日本ビタミン学会
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詳細情報 詳細情報について
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- CRID
- 1390001205702028672
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- NII論文ID
- 110006596183
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- NII書誌ID
- AN00207833
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- ISSN
- 2424080X
- 0006386X
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- NDL書誌ID
- 9389005
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
