書誌事項
- タイトル別名
-
- Evaluation of the Biological Action Mechanism of Vitamin K Homologues with Chemical Techniques
- カガクテキ アプローチ ニ ヨル ビタミン K ノ セイリ サヨウ ノ カイセキ ト セイリ カッセイ ブッシツ エ ノ オウヨウ
この論文をさがす
抄録
Vitamin K is a fat-soluble vitamin and a well-known cofactor for γ-glutamyl carboxylase (GGCX), an enzyme that converts specific glutamic acid residues in several proteins to γ-carboxyglutamic acid (Gla) residues related to blood coagulation and bone formation in the vitamin K cycle. It has two major homologues, the plant-derived vitamin K_1 (phylloquinone: PK)and the bacterium-derived vitamin K_2 (menaquinone-n: MK-n). Among these homologues, MK-4 has attracted attention because of its interesting biological activities. For example, MK-4 showed additional biological actions related to gene transcription through the steroid and xenobiotic receptor (SXR), suppression of cancer cell proliferation, and so on. Therefore, we evaluated the biological action of vitamin K homologues with chemical techniques using heavy oxygen labeled, fluorescent labeled, and deuterated labeled analogues. Furthermore, we also elucidated new analogues with high rates of conversion to MK-4. Those analogues can be expected to lead to new drugs once the biological importance of MK-4 is clarified.
収録刊行物
-
- ビタミン
-
ビタミン 85 (5-6), 271-279, 2011
公益社団法人 日本ビタミン学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001205702191616
-
- NII論文ID
- 110008686087
-
- NII書誌ID
- AN00207833
-
- ISSN
- 2424080X
- 0006386X
-
- NDL書誌ID
- 11161103
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- NDL
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可