Studies on the Transport Functions and Cell-Cell Interactions in the Intestinal Epithelium

SHIMIZU Makoto, SATSU Hideo

doi:10.20632/vso.78.11_555

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小腸粘膜上皮における物質輸送機能と細胞間相互作用の解析(ビタミン・バイオファクターの新展開 : 健康と食)
小腸粘膜上皮における物質輸送機能と細胞間相互作用の解析
ショウチョウネンマクジョウヒニオケルブッシツユソウキノウトサイボウカンソウゴサヨウノカイセキ

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Abstract

Intestine is an organ responsible for nutrient absorption. Recent studies have demonstrated that certain food substances modulate intestinal digestion and transport functions. Since the foods containing those substances are expected to alter the levels of blood glucose, cholesterol, minerals and so on, some of those foods have been approved as "Food for specified health uses"(FOSHU). Cell culture systems have provided useful means to study intestinal functions. Human intestinal Caco-2 cells are used as a good model to evaluate the intestinal absorption of food substances. Caco-2 cells are also useful to analyze intestinal epithelial cell responses to such external factors as food components and xenobiotics. Cell-cell interactions in the intestinal epithelium can also be investigated by using Caco2 cells. Coculture systems have demonstrated that Caco-2 cells interact with neuronal cells and immune cells. These systems will provide useful information on intestinal functions and also be beneficial for the development of intestine-modulatory functional foods.

Journal

VITAMINS

VITAMINS 78 (11), 555-563, 2004

THE VITAMIN SOCIETY OF JAPAN

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