The expression of osteoprotegerin in human periodontal ligament cells stimulated by continuous and intermittent forces

DOI
  • Nakao Kayoko
    Division of Orofacial Functions and Orthodontics, Department of Growth and Development of functions, Kyushu Dental College
  • Goto Tetsuya
    Division of Anatomy, Department of Biosciences, Kyushu Dental College
  • Gunnjigake Kaori
    Division of Orofacial Functions and Orthodontics, Department of Growth and Development of functions, Kyushu Dental College
  • Yoshida Akihiro
    Division of Community Oral Health Science, Department of Health Promotion, Kyushu Dental College
  • Konoo Tetsrou
    Division of Orofacial Functions and Orthodontics, Department of Growth and Development of functions, Kyushu Dental College
  • Kobayashi Shigeru
    Division of Anatomy, Department of Biosciences, Kyushu Dental College
  • Yamaguchi Kazunori
    Division of Orofacial Functions and Orthodontics, Department of Growth and Development of functions, Kyushu Dental College

Bibliographic Information

Other Title
  • 持続的および間歇的加圧刺激によるヒト歯根膜細胞のOsteoprotegerinの発現について

Abstract

Bone resorption in compressive side is performed by osteoclasts during orthodontic tooth movement. The differentiation of osteoclasts is regulated by the expressions of OPG and RANKL. In this study we investigated the expressions of OPG and RANKL mRNA in human periodontal ligament cells stimulated by continuous and intermittent compressive forces. PDL cells were compressed (0, 2.0, 5.0 g/cm2). We examined the expressions of OPG and RANKL mRNA semi-quantitatively by RT-PCR. The expression of OPG mRNA in PDL cells under compressive force was decreased in force- and time- depedent manner and the expression of OPG under intermittent force was greater than that under continuous force. The expression of RANKL mRNA under intermittent force was greater than that under continuous force. These findings suggested that OPG related bone resorption in compressive side and the intermittent force was more effective in orthodontic treatment.

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Keywords

Details 詳細情報について

  • CRID
    1390001205713288192
  • NII Article ID
    130007022000
  • DOI
    10.11495/jkds.kds65.0.8.0
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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