Brain mechanism of atypical sexual identity, based on the gonadotropin secretory pattern in female-to-male transsexuals
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- Kimura Fukuko
- Dept. Neuroendocrinol., Yokohama City Univ. Graduate Sch. Med., Yokohama, Japan
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- Funabashi Toshiya
- Dept. Neuroendocrinol., Yokohama City Univ. Graduate Sch. Med., Yokohama, Japan
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- Kihara Akira
- Dept. Neuroendocrinol., Yokohama City Univ. Graduate Sch. Med., Yokohama, Japan
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- Sakakibara Hideya
- Dept. Obst. Gynecol. Mol. Reprod. Sci., Graduate Sch. Med., Yokohama, Japan
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- Hirahara Fumiki
- Dept. Obst. Gynecol. Mol. Reprod. Sci., Graduate Sch. Med., Yokohama, Japan
Bibliographic Information
- Other Title
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- 女性から男性への性転換症者の性腺刺激ホルモン分泌パターンから見た非典型的性アイデンティティの脳基盤
Abstract
The central part of the bed nucleus of the stria terminalis was shown to be sexually dimorphic, i.e., smaller in women, with a female volume and neuron number in male-to-female transsexuals. The interstitial nuclei of the anterior hypothalamus (INAH) 3 was also sexually dimorphic, i.e., more than twice as large in heterosexual men than in homosexual men. These findings indicate that each sexual identity and sexual orientation has a different biological substrate. We studied the gonadotropin secretory pattern in 4 21-27 year-old female-to-male transsexual women (FTMs). In 2 FTMs, the surge secretion of LH was atypical, showing extremely low amplitudes, in accord with the clinical diagnosis of anovulatory menstrual cycles based on the basal body temperature (BBT), whereas pulsatile secretions of LH in both follicular and luteal phases were typical. One of these FTMs was bisexual and another homosexual. Two other FTMs showed almost typical LH secretory patterns and BBT during the cycle, being homosexual. Although it is controversial whether the control mechanism for gonadotropin secretion in the human hypothalamus is sexually dimorphic, we assume that FTMs are atypical not only in sexual identity, but also in sexual orientation and the control of gonadotropin secretion, suggesting that they have a general hypothalamic sexual differentiation disorder (GHSDD). [Jpn J Physiol 54 Suppl:S41 (2004)]
Journal
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- Proceedings of Annual Meeting of the Physiological Society of Japan
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Proceedings of Annual Meeting of the Physiological Society of Japan 2004 (0), S41-S41, 2004
PHYSIOLOGICAL SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390001205727103360
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- NII Article ID
- 130005447311
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed