Helicobacter pylori誘起胃炎に対するグルタミン酸添加食の保護効果
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- 中村 英志
- Institute of Life Sciences, Ajinomoto Co., Inc. Kawasaki, Japan
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- 天ヶ瀬 紀久子
- Dept. of Pharmacology & Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
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- 蓮村 麻衣
- Institute of Life Sciences, Ajinomoto Co., Inc. Kawasaki, Japan
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- サンガブリエル アナ
- Institute of Life Sciences, Ajinomoto Co., Inc. Kawasaki, Japan
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- 畝山 寿之
- Institute of Life Sciences, Ajinomoto Co., Inc. Kawasaki, Japan
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- 鳥居 邦夫
- Institute of Life Sciences, Ajinomoto Co., Inc. Kawasaki, Japan
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- 竹内 孝治
- Dept. of Pharmacology & Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
書誌事項
- タイトル別名
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- Glutamate supplementation protects gerbil gastric mucosa against Helicobacter pylori
抄録
Backgrounds & Aims: The importance of urease-derived ammonia in the pathogenesis of Helicobacter pylori (H. pylori)-induced gastric diseases is known by the fact that Helicobacter felis (expresses urease but not vac A or cag PAI-related gene products) induces gastritis and gastric cancer in animal models. Glutamate is previously reported to protect cultured gastric epithelial cells against ammonia (Nakamura & Hagen, Am J Physiol 283: G1264, 2002). However, whether glutamate protects in vivo gastric mucosa against H. pylori is still unknown. Thus, we examined the effect of glutamate supplementation on H. pylori-induced gastric mucosal damage using gerbil model.Materials & Methods: The diets with or without glutamate supplementation were fed to H. pylori-infected Mongolian gerbils for 3 months, then the gastric mucosa were used for the macroscopic, histochemical analyses. The number of viable H. pylori in the stomach was also determined. Results & Discussion: Glutamate supplementation significantly suppressed H. pylori-induced gastric mucosal damage and inflammatory cell infiltration. Interestingly, the number of viable H. pylori in the stomach was unchanged between the diet with and without glutamate.Conclusion: Glutamate supplementation protects H. pylori-induced gastric mucosal damage without affecting H. pylori itself, suggesting the stimulatory role of glutamate on gastric defensive factors. [J Physiol Sci. 2008;58 Suppl:S214]
収録刊行物
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- 日本生理学会大会発表要旨集
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日本生理学会大会発表要旨集 2008 (0), 214-214, 2008
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205729817472
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- NII論文ID
- 130005449854
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
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