蛋白質合成・BDNF依存的な樹状突起スパイン形態可塑性
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- 河西 春郎
- CDBIM, Grad. Sch. Med. Univ. Tokyo, Tokyo, Japan
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- 田中 淳一
- CDBIM, Grad. Sch. Med. Univ. Tokyo, Tokyo, Japan
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- 松崎 政紀
- CDBIM, Grad. Sch. Med. Univ. Tokyo, Tokyo, Japan PRESTO, JST, Saitama, Japan
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- エリスデビス グラハム
- Dept. Pharmac.Physiol., Drexel Univ., Philadelphia, PA 19102, USA
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- 宮崎 崇史
- CDBIM, Grad. Sch. Med. Univ. Tokyo, Tokyo, Japan
書誌事項
- タイトル別名
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- Protein-synthesis and neurotrophin dependent structural plasticity in single dendritic spines
説明
Long-term potentiation (LTP) at glutamatergic synapses is considered to underlie learning and memory, and is associated with enlargement of dendritic spines. Since consolidation of memory and LTP requires protein synthesis, it is important to clarify how protein synthesis affects spine enlargement. We here report that repetitive pairing of postsynaptic spikes and two-photon uncaging of glutamate at single spines (spike-timing protocol) displayed both immediate and gradual phases of spine enlargement in CA1 pyramidal neurons. The gradual enlargement was strongly dependent on protein-synthesis and BDNF action, often associated with spine twitching, and was induced specifically at the spines which were immediately enlarged by the synaptic stimulation. Thus, spike-timing protocol is an efficient trigger for BDNF secretion, and induces protein-synthesis dependent long-term enlargement at the level of single spines. [J Physiol Sci. 2008;58 Suppl:S6]
収録刊行物
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- 日本生理学会大会発表要旨集
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日本生理学会大会発表要旨集 2008 (0), 006-006, 2008
一般社団法人 日本生理学会
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詳細情報 詳細情報について
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- CRID
- 1390001205729960192
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- NII論文ID
- 130007039544
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
