Application for Dry Powder Inhaler by using a Spouted Bed Binderless Granulation
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- Nakamura Nobuyuki
- Department of Chemical Engineering, Nagoya University, Japan
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- Hatano Shigenobu
- Department of Chemical Engineering, Nagoya University, Japan
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- Kobayashi Nobusuke
- Department of Chemical Engineering, Nagoya University, Japan
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- Kobayashi Jun
- Center for Cooperative Research in Advanced Science and Technology, Nagoya University, Japan
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- Itaya Yoshinori
- Department of Chemical Engineering, Nagoya University, Japan
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- Mori Shigekatsu
- Center for Cooperative Research in Advanced Science and Technology, Nagoya University, Japan
説明
In the medicine preparation field, the development of dry powder inhaler (DPI) attracts attention recently. DPI is fine powder (0.5 to 7 µm) type medicine, which can be taken up directly to the lung cells through the DPI device. Since the handling of the fine powder is very difficult due to the very strong cohesive force, the granulation techniques are usually applied for the better handling in the medicine preparation. However, DPI is also required a moderate granule weakness which can be broken into initial particle size to be reached to the lung. Therefore, because of the high granule strength, the conventional binder type granulation techniques can not be applied for the DPI application. <BR>In this study, the new binderless granulation technique for DPI was developed by using a spouted fluidized bed granulator. This experiment was carried out in the different granulation conditions and the quality of produced granule was evaluated. The granulation condition was changed in velocity of fluidization gas, size of raw material and type of powder material. As a result, it was found that obtained granule by the new granulation method had a moderate strength for DPI.
収録刊行物
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- アジア・太平洋化学工学会議発表論文要旨集
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アジア・太平洋化学工学会議発表論文要旨集 2004 (0), 966-966, 2004
公益社団法人 化学工学会
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詳細情報 詳細情報について
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- CRID
- 1390001205732169728
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- NII論文ID
- 130005053069
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
