A Case of TEN Induced by Telaprevil and Having a DIHS-like Clinical Course

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  • Yamamoto Saori
    Department of Dermatology, Faculty of Medicine, University of Yamanashi
  • Harada Kazutoshi
    Department of Dermatology, Faculty of Medicine, University of Yamanashi
  • Andou Noriko
    Department of Dermatology, Faculty of Medicine, University of Yamanashi
  • Aoki Rui
    Department of Dermatology, Faculty of Medicine, University of Yamanashi
  • Kawamura Tatsuyoshi
    Department of Dermatology, Faculty of Medicine, University of Yamanashi
  • Shibagaki Naotaka
    Department of Dermatology, Faculty of Medicine, University of Yamanashi
  • Shimada Shinji
    Department of Dermatology, Faculty of Medicine, University of Yamanashi

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Other Title
  • DIHSの病態をとったテラプレビルによるTENの1例
  • DIHS ノ ビョウタイ オ トッタ テラプレビル ニ ヨル TEN ノ 1レイ

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Abstract

A 50-year-old female visited our clinic complaining of erythematous papules on her breast, chest and thighs after starting IFNα2b, ribavirin and telaprevir for chronic hepatitis C. The skin rash disappeared with topical steroid application, however, the eruption relapsed after one month. Although drugs for hepatitis including telaprevir were discontinued and systemic administration of steroid started, her skin eruptions were exacerbated with eosinophilia and reactivation of HHV-6. The patient received steroid plus therapy followed by plasma pheresis and intravenous immunoglobulin and her skin eruptions gradually improved. We diagnosed this case as TEN induced by telaprevir with a DIHS-like clinical course. Although skin rashes are common with the use of telaprevir and most eruptions usually disappear eventually with continuation of this drug, telaprevir may cause a severe skin reaction such as that reported here. Dermatologists should pay attention to eruptions caused by telaprevir.

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