A Report of Three Cases with Specific Skin Lesions in Acute Myeloid Leukemia

DOI Web Site 15 References
  • Kan Keiko
    Kan Clinic of Orthopedics and Dermatology Department of Pathology, Iwate Medical University, School of Medicine Department of Dermatology, Iwate Medical University, School of Medicine
  • Satoh Takashi
    Department of Pathology, Iwate Medical University, School of Medicine
  • Sakurai Eiichi
    Department of Pathology, Iwate Medical University, School of Medicine Department of Dermatology, Iwate Medical University, School of Medicine
  • Akasaka Kiyomi
    Department of Pathology, Iwate Medical University, School of Medicine Department of Dermatology, Iwate Medical University, School of Medicine
  • Ishida Youji
    Department of Oncology and Hematology, Iwate Medical University, School of Medicine
  • Akasaka Toshihide
    Department of Dermatology, Iwate Medical University, School of Medicine
  • Masuda Tomoyuki
    Department of Pathology, Iwate Medical University, School of Medicine

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Other Title
  • 皮膚特異疹を呈した急性骨髄性白血病の3例
  • ヒフ トクイシン オ テイシタ キュウセイ コツズイセイ ハッケツビョウ ノ 3レイ

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Description

We describe 3 patients with acute myeloid leukemia (AML) who had skin infiltrations of leukemic cells. Case 1 was a 73-year-old man with red-infiltrated erythema on his face, trunks, shoulder, and inguinal region. Case 2 was a 74-year-old woman with a pruritic red-brownish eruption on her trunk. Case 3 was a 27-year-old woman; cutaneous nodules appeared on her head 40 months after chemotherapy and a peripheral blood stem cell transplantation for AML. The histology of the skin biopsy specimens of all 3 cases revealed dense infiltrations of blasts that were immunoreactive for myeloperoxidase and CD68. In Cases 1 and 2, bone marrow examination disclosed AML. The skin lesions disappeared after chemotherapy for AML in the first 2 cases and after irradiation in the last case. Macroscopic findings in the specific skin lesions varied among the cases. Specific skin lesions are important for diagnosis of the first evidence of AML or as extramedullary manifestations of relapse in a previously treated AML case in remission.

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