A Case of Anaphylaxis due to Cochineal Extract
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- Takeo Naoko
- Department of Anatomy Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
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- Senba Kyoko
- Department of Anatomy Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
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- Katagiri Kazumoto
- Department of Anatomy Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
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- Fujiwara Sakuhei
- Department of Anatomy Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
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- Hiroshige Shigeo
- Department of Respiratory Medicine, Shinbeppu Hospital
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- Onishi Kuniyoshi
- San-Ei Gen F. F. I., Inc.
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- Suzuki Yukio
- San-Ei Gen F. F. I., Inc.
Bibliographic Information
- Other Title
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- コチニール色素によるアナフィラキシーの1例
- コチニール シキソ ニ ヨル アナフィラキシー ノ 1レイ
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Abstract
A 23-year-old female had presented with a one year history of four episodes of urticaria and angioedema, which had been getting more severe. During the last episode, she suffered generalized urticaria, perioral and perioribital angioedema, and dyspnea requiring emergency treatment after the ingestion of several foods and drinks including Campari-Orange. After the treatment, she visited our clinic to determine the cause of her symptoms. We found no correlation between any the common foods or drugs and her episodes. Challenge tests with several food additives, food colorings, and aspirin were negative. Challenge tests after taking aspirin with individual or complex ingestion of several foods and drinks that she had taken during her episodes gave positive results for strawberry milk (dairy drinks including fruit juice) made by A company, fish sausage made by B company, and Campari (liqueur) imported from Italy. A challenge test after taking aspirin also gave positive results for cochineal extract which is commonly included in these foods and drinks, but a high dose of cochineal extract was required for the results. Western blotting analysis revealed the presence of cochineal-extract-specific IgE antibodies in patient’s serum that react to four bands at about 40kDa. Physicians should be aware of the possibility of rare but important adverse effects to cochineal extract, which is sometimes listed as carmic acid.
Journal
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- The Japanese Journal of Dermatology
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The Japanese Journal of Dermatology 118 (6), 1085-1093, 2008
Japanese Dermatological Association
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Keywords
Details 詳細情報について
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- CRID
- 1390001205736021888
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- NII Article ID
- 130004708603
- 10028276158
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- NII Book ID
- AN00196602
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- ISSN
- 13468146
- 0021499X
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- NDL BIB ID
- 9521148
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed