GW501516 acts as an efficient PPARα activator in the mouse liver

DOI 19 References
  • Terada Masahiro
    Department of Biochemistry, Meiji Pharmaceutical University
  • Araki Makoto
    Department of Biochemistry, Meiji Pharmaceutical University Department of Molecular Biology, School of Pharmacy, Iwate Medical University
  • Ashibe Bunichiro
    Department of Biochemistry, Meiji Pharmaceutical University Central Research Center, Yomeishu Seizo Co., Ltd
  • Motojima Kiyoto
    Department of Biochemistry, Meiji Pharmaceutical University

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Abstract

The peroxisome proliferator-activated receptor (PPAR) subtype specificity of GW501516, a well-known PPARδ-specific agonist, was studied by examining its effects on the expression of endogenous genes in primary hepatocytes and the liver of wild-type and PPARα-null mice. GW501516, like the PPARα-specific agonist Wy14,643, induced the expression of several PPAR target genes in a dose-dependent manner but this action was mostly absent in the cells and liver of PPARα-null mice. Results indicated that GW501516 acts as an efficient PPARα activator in the mouse liver.

Journal

  • Drug Discoveries & Therapeutics

    Drug Discoveries & Therapeutics 5 (4), 176-180, 2011

    International Research and Cooperation Association for Bio & Socio-Sciences Advancement

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