Oxoprothracarcin, a novel pyrrolo[1,4]benzodiazepine antibiotic from marine Streptomyces sp. M10946

  • Han Yong
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Li Yaoyao
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Shen Yan
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University
  • Li Jie
    Yunnan Institute of Microbiology, Yunnan University
  • Li Wenjun
    Yunnan Institute of Microbiology, Yunnan University
  • Shen Yuemao
    Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University

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  • Oxoprothracarcin, a novel pyrrolo[1,4]benzodiazepine antibiotic from marine <i>Streptomyces</i> sp. M10946

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説明

A novel pyrrolo[1,4]benzodiazepine antibiotic, designated oxoprothracarcin (3), was isolated from the marine strain Streptomyces sp. M10946 along with three known secondary metabolites, cyclo(D)-Pro-(D)-Val (1), cyclo(D)-Pro(D)-Leu (2), and limazepine A (4). The chemical structures of these substances were elucidated by spectroscopic analyses, including 1D- and 2D-NMR and ESI-MS. Antitumor and antibacterial assays indicated that compounds 1-4 weakly inhibit the growth of MDA-MB-231 and A549 cells. The isolation of compound 3 with a high yield (36 mg/10 L) indicated that this marine S. sp. M10946 may provide new lead compounds for structural modification and drug screening.

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  • Drug Discoveries & Therapeutics

    Drug Discoveries & Therapeutics 7 (6), 243-247, 2013

    特定非営利活動法人 バイオ&ソーシャル・サイエンス推進国際研究交流会

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