Focused libraries to accelerate drug discovery

DOI

Bibliographic Information

Other Title
  • 創薬を加速するフォーカストライブラリー

Description

Although high throughput screening (HTS) of millions of compounds in the early stage of drug discovery has become very common, it is not necessarily cost effective. Therefore, designing focused libraries targeting certain proteins is recently receiving more attention. PharmaDesign virtually screens millions of compounds against 3-D structures of target proteins in silico, and designs focused libraries. We designed focused libraries for chemokine receptors, a family of G-protein coupled receptors (GPCRs), which are known to have very limited structure information available. When an inhibitory assay was conducted against one of the chemokine receptors, CCR4, the hit rate was 13.3%. Furthermore, we designed focused libraries for DAP(Death Associated Protein) family, which regulates apoptosis/autophagy. We believe that focused libraries designed based on 3-D structures of target proteins significantly contribute to more efficient identification of hit compounds, and accelerate drug discovery process.

Journal

Keywords

Details 詳細情報について

  • CRID
    1390001205736356224
  • NII Article ID
    130004574899
  • DOI
    10.11545/ciqs.2006.0.jl2.0
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

Report a problem

Back to top